Phytochemistry, anti-asthmatic and antioxidant activities of Anchomanes difformis (Blume) Engl. leaf extract
Asian Pacific Journal of Tropical Biomedicine
;
(12): 225-231, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-950843
ABSTRACT
Objective:
To study the phytochemistry, anti-asthmatic and antioxidant activities of the aqueous leaf extract of Anchomanes difformis (Blume) Engl. (A. difformis) and to verify claims of use in folk medicine.Methods:
For anti-asthmatic activity, male and female guinea pigs with average body weight of (451.4 ± 118.1) g were divided into six groups of six animals each. Group 1 served as control (distilled water); Group 2 was administered with salbutamol (reference drug) only; Group 3 served as ovalbumin sensitized group, Group 4, 5 and 6 were treated with A. difformis extract at doses of 100, 200 and 400 mg/kg, respectively. Described methods were used to test fluid viscosity, fluid volume and quantitative phytochemistry analysis. Absorbance was read using a UV-Vis spectrophotometer and results computed in percentage. Total antioxidant assays [2, 2-diphenyl-1-picrylhydrazyl (DPPH) and lipid peroxidation assay], were carried out using reported procedures.Results:
The anti-asthmatic evaluation showed that protection from asthma of the animals in Group 6 (400 mg/kg, 32.7%) were similar to that in Group 2 (salbutamol, 33.0%). Excised trachea was free of mucus secretion in Group 5 (200 mg/kg) as was observed in the control group. Fluid volume increase in Groups 3 and 6 indicated mucus secretion. DPPH radical scavenging activity of extract was effective as ascorbic acid which served as standard at 20 μg/mL. But, the extract elicited low lipid peroxidation activity compared with the reference (tocopherol) at concentrations tested.Conclusions:
A. difformis aqueous leaf extract is safe and possesses positive anti-asthmatic and antioxidant activities as claimed by traditional herbal practitioners in Delta State.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Asian Pacific Journal of Tropical Biomedicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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