Clinicopathologic Correlations of E-cadherin and Prrx-1 Expression Loss in Hepatocellular Carcinoma
Journal of Pathology and Translational Medicine
;
: 327-336, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-9510
ABSTRACT
BACKGROUND:
Developing predictive markers for hepatocellular carcinoma (HCC) is important, because many patients experience recurrence and metastasis. Epithelial to mesenchymal transition (EMT) is a developmental process that plays an important role during embryogenesis and also during cancer metastasis. Paired-related homeobox protein 1 (Prrx-1) is an EMT inducer that has recently been introduced, and its prognostic significance in HCC is largely unknown.METHODS:
Tissue microarray was constructed using surgically resected primary HCCs from 244 cases. Immunohistochemical staining of E-cadherin and Prrx-1 was performed. The correlation between E-cadherin loss and Prrx-1 expression, as well as other clinicopathologic factors, was evaluated.RESULTS:
E-cadherin expression was decreased in 96 cases (39.4%). Loss of E-cadherin correlated with a higher recurrence rate (p 40%) were independent prognostic factors for shorter overall survival.CONCLUSIONS:
Prrx-1 was expressed in small portions of HCCs but not in normal livers. Additional studies with a large number of Prrx-1-positive cases are required to confirm the results of this study.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Fibrose
/
Caderinas
/
Modelos de Riscos Proporcionais
/
Genes Homeobox
/
Estudos de Coortes
/
Carcinoma Hepatocelular
/
Intervalo Livre de Doença
/
Desenvolvimento Embrionário
/
Transição Epitelial-Mesenquimal
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Journal of Pathology and Translational Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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