Netrin-1: The new tumor markers in renal clear cell carcinoma
Asian Pacific Journal of Tropical Medicine
;
(12): 489-493, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-951602
ABSTRACT
Objective:
To explore the expression of Netrin-1 protein in human renal clear cell carcinoma (RCCC) and the relationships between Netrin-1, pathology and prognosis.Methods:
72 cases of RCCC admitted in our hospital from 2008 June to 2009 June and their adjacent tissues were selected for study. They included 30 cases in stage I-II, 42 cases in stage III-IV; 9 cases in grade I, 9 cases in grade II, 40 cases in grade III and 14 cases in grade IV. All cases were followed up for more than 5 years. Survival analysis lines were made by Kaplan-Meier method and the difference between groups was tested by the Log-rank test. The expression of Netrin-1 protein was detected by immunohistochemistry staining and its clinical significance was analyzed.Results:
Renal clear cell carcinoma 51 cases in high expression of Netrin-1 and 21 cases in low expression, normal tissues 12 cases in high expression of Netrin-1 and 60 cases in low expression, the difference between the two groups is significant (χ2=42.921, P2=8.000, χ2=6.203; P2=1.360, P=0.245).Conclusions:
Netrin-1 protein plays an important role in the development of RCCC. It might be a new specific tumor marker of RCCC, and might become a new target in treatment of RCCC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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