High dose exposures of vinyl acetate induce neoplastic transformation of human epithelial cells in culture
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 437-444, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-95184
ABSTRACT
Vinyl acetate has been widely used for the manufacture of polyvinyl alcohol emulsion, which is primary ingredient of adhesive, paints, textile, paperboard coatings, etc. Since these products are plentiful and frequently used around us, workers and consumers are at health risk. International Agency for Research on Cancer (IARC) classified vinyl acetate as group 2B (possibly carcinogenic to humans). Among the organs targeted, the oral cavity is the most vulnerable organ affected by the carcinogenic effects of vinyl acetate. Since the origin of most of oral cancer is derived from the epithelial cells, it is important to understand the carcinogenic potential of vinyl acetate in human epithelial cells. Thus, the present study has attempted to utilize the immortalized human epithelial cell model to assess the carcinogenic potency of this chemical and to understand the underlying mechanisms.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pintura
/
Álcool de Polivinil
/
Têxteis
/
Agências Internacionais
/
Neoplasias Bucais
/
Adesivos
/
Células Epiteliais
/
Boca
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS