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Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida
Article em Zh | WPRIM | ID: wpr-951909
Biblioteca responsável: WPRO
ABSTRACT
Objective: To investigate the antileishmanial, antimicrobial and antimalarial activities of the pure metabolites from Jatropha multifida used in African ethnomedicine. Methods: The methanolic stem bark extract of Jatropha multifida used in Nigerian folk medicine as remedy against bacterial infections was subjected to column chromatography and HPLC analyses to obtain three known metabolites, microcyclic lathyrane diterpenoids (1-3). Structures were confirmed by comparison of 1D and 2D spectral data with literature. Results: The three compounds exhibited inhibition of antileishmanial, antimalarial and antimicrobial actions against the tested organisms with compouds 2 and 3 active against Cryptococcus neoformans at IC
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Asian Pacific Journal of Tropical Biomedicine Ano de publicação: 2014 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Asian Pacific Journal of Tropical Biomedicine Ano de publicação: 2014 Tipo de documento: Article