Expression of Fibroblast Growth Factor Receptor 3 in the Recurrence of Non-Muscle-Invasive Urothelial Carcinoma of the Bladder
Korean Journal of Urology
;
: 94-100, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-95244
ABSTRACT
PURPOSE:
The fibroblast growth factor receptor 3 (FGFR3) gene is known to be frequently mutated in noninvasive urothelial carcinomas of the bladder. In this study, we investigated the expression of FGFR3, Ki-67, and p53 in bladder cancers and the effects of expression on tumor recurrence. MATERIALS ANDMETHODS:
Fifty-five cases of primary bladder cancer were examined by immunohistochemistry. The relationship of these markers with various clinicopathological factors, including recurrence, was assessed.RESULTS:
Positivity for cytoplasmic FGFR3 (FGFR3-c) was associated with a lower cancer grade (p=0.022) and stage (p=0.011). Recurrence was more frequent in patients with a higher stage, negative FGFR3-c, and high Ki-67 expression. According to univariate analysis, predictors of recurrence-free survival included the following age, stage, FGFR-c, Ki-67, and p53. However, none of these was independent from the other parameters in multivariate studies.CONCLUSIONS:
The immunohistochemical expression of FGFR3 is not only one of the characteristic features of lower-grade and lower-stage urothelial carcinoma but also a possible marker in predicting disease recurrence.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Imuno-Histoquímica
/
Carcinoma de Células de Transição
/
Genes p53
/
Receptores de Fatores de Crescimento de Fibroblastos
/
Citoplasma
/
Receptor Tipo 3 de Fator de Crescimento de Fibroblastos
/
Fatores de Crescimento de Fibroblastos
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Urology
Ano de publicação:
2010
Tipo de documento:
Artigo
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