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Functional and binding studies of gallic acid showing platelet aggregation inhibitory effect as a thrombin inhibitor / 中草药·英文版
Chinese Herbal Medicines ; (4): 303-309, 2022.
Artigo em Chinês | WPRIM | ID: wpr-953589
ABSTRACT

Objective:

This study was devoted to identifying natural thrombin inhibitors from traditional Chinese medicine (TCM) and evaluating its biological activity in vitro and binding characteristics.

Methods:

A combination strategy containing molecular docking, thrombin inhibition assay, surface plasmon resonance (SPR) and molecular dynamics simulation were applied to verify the study result.

Results:

Gallic acid was confirmed as a direct thrombin inhibitor with IC

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Herbal Medicines Ano de publicação: 2022 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Herbal Medicines Ano de publicação: 2022 Tipo de documento: Artigo