Anticancer Effect of Selenium / 이화의대지
The Ewha Medical Journal
;
: 17-21, 2017.
Artigo
em Coreano
| WPRIM
| ID: wpr-95361
ABSTRACT
Selenium is an essential microelement in animals including human. Selenium plays an important role in cellular functions such as deoxygenation and detoxification. Also, it can be used in treatment of cardiac disease, hepatic disease, AIDS and various cancers. Recent meta-analysis showed that high selenium exposure was associated with decreased risk of several cancers. Selenium has an effect on anticarcinogesis through several mechanisms, which are regulation of cell cycles, apoptosis, DNA damage and repair, inhibition of cellular adhesion and migration, anti-angiogenesis and immune modulation. Even though many laboratory studies have provided convincing evidence of these mechanisms, results from epidemiologic and clinical studies of selenium does not coincide with each other. Well-designed trials considering dosage and chemical form of selenium supplement as well as confounding factors and long-term follow-up of them would be needed to use selenium in chemoprevention and therapy of cancers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Selênio
/
Dano ao DNA
/
Ciclo Celular
/
Seguimentos
/
Apoptose
/
Quimioprevenção
/
Cardiopatias
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
The Ewha Medical Journal
Ano de publicação:
2017
Tipo de documento:
Artigo
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