Analgesic alkaloids from Urticae Fissae Herba / 中草药·英文版
Chinese Herbal Medicines
;
(4): 125-129, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-953610
ABSTRACT
Objective:
To investigate the analgesic substances in the aerial part of Urtica fissa (Urticae Fissae Herba), commonly used for rheumatoid and rheumatism arthritis.Methods:
The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models, and identified by comprehensive spectroscopic analysis.Results:
Thirteen alkaloids (1–13), two lignans (14, 15), and three amides (16–18) were isolated from the active fractions. Among them, compound 1 was a new alkaloid, and compound 6 was a new natural product. The activity evaluation in vivo indicated that various pyrrole alkaloids (1, 3, 6, and 12) possessed significant analgesic activities, they could significantly inhibit the mice pain response induced by acetic acid and hot plate at the dosage of 2 mg/kg BW.Conclusion:
The study revealed that the pyrrole alkaloids played important roles in the analgesic activities of Urticae Fissae Herba.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Herbal Medicines
Ano de publicação:
2022
Tipo de documento:
Artigo
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