Matrix Metalloproteinase-2 Associated with Cerebral Ischemic Injury and Recovery (review) / 中国康复理论与实践

ABSTRACT

@#Matrix metalloproteinase-2 (MMP-2), which is a member of MMP family, can degrade extracellular matrix. During the early stage of cerebral ischemia, MMP-2 degrades endothelial tight junction and basal lamina resulting in the opening of blood-brain barrier. During the late stage, MMP-2 promotes neurovascular regeneration and the recovery of the damaged brain tissue.