The role of autophagy in the pathogenesis of children immune thrombocytopenia / 国际儿科学杂志

ABSTRACT

Immune thrombocytopenia (ITP) is a common hemorrhagic disorder among children.Its pathogenesis is mainly based on impaired platelet production or increased platelet destruction.The development of ITP is not just due to abnormalities in the immune system.With the role of autophagy being revealed, more and more studies have proven its importance in hematopoietic stem cells, megakaryocytes and platelets.The paper aims to review the role of autophagy in the pathogenesis of ITP.