Advance in the immunologic mechanism and mucosal immunity of Bordetella pertussis / 国际儿科学杂志

ABSTRACT

Pertussis, or whooping cough, is a highly contagious respiratory disease.Despite the implementation of the universal immunization program, pertussis remains a significant public health problem.Existing pertussis vaccines have a poorly controlled effect, and new vaccines are needed to protect against pertussis disease, as well as to prevent infection and transmission of Bordetella pertussis.The development of new pertussis vaccines requires an in-depth study of pertussis′s pathogenesis and immune mechanism, especially the protective immune mechanism.With the further understanding of the protective immune mechanism, the mucosal vaccine has been paid more attention, and new approaches, such as nasal immunization, outer membrane vesicles, and live attenuated vaccine have been adopted.This paper summarizes pertussis′s immune mechanism and mucosal immunity to provide ideas for the research and development of new pertussis vaccines.