Update on epidemiology, treatment and genetics of purulent meningitis in children / 国际儿科学杂志

ABSTRACT

Purulent meningitis(PM)is the main reasons of infectious diseases in the central nervous system of children.It is one of the leading causes of neurological sequelae in children.Pathogens are related to region, socioeconomic status, environment, age, etc.The epidemiology has been changing owing to the increasing vaccination coverage rate.Streptococcus pneumoniae, Staphylococcus epidermidis, Escherichia coli and group B Streptococcus are the main pathogens of PM in children.Antibiotics are the main treatment.Corticosteroids are controversial in the treatment of PM.Vaccination is the main method to prevent PM and its complications.With the development of genetics, the genetic variation of immune system has been proved to be related to the susceptibility of PM.This article reviews recent advances in epidemiological changes, treatment, and genetic associations of PM in children.It is helpful for the diagnosis and treatment of PM.