Mechanism of ROS activate TGF-β1 pathway to regulate airway epithelial mesenchymal transition in asthma / 国际儿科学杂志

ABSTRACT

Bronchial asthma is a common chronic respiratory disease.Its pathogenesis is complex and still unclear.Recent studies have found that oxidative stress plays an important role in the development of bronchial asthma.When oxidative stress injury occurs in asthma airway, epithelial cells release a large amount of reactive oxygen species(ROS)to activate multiple signaling pathways mediated by transforming growth factor-beta 1(TGF-β1), and then induce epithelial mesenchymal transition(EMT)to participate in airway remodeling.This article reviews the mechanism of ROS activate TGF-β1 to induce EMT in asthma, aiming to seek a new theoretical basis for airway remodeling in asthmatic airway, and to provide a theoretical basis for the treatment of airway remodeling in asthma.