Methyltransferase like protein 14 and tumor / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 478-483, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-954308
ABSTRACT
N 6-methyladenosine (m 6A) modification, as the most prevalent epigenetic modification of RNA, plays a crucial role in the initiation and development of malignancies. Methyltransferase like protein 14 (METTL14) is a major methylase catalyzing m 6A modification and regulating biological processes such as RNA splicing, translation and degradation. Recent studies have demonstrated that METTL14 not only regulates the growth, invasion and metastasis of tumors through various molecular mechanisms, but also is closely correlated with the prognosis of tumor patients and clinical efficacy of anti-tumor therapies. In-depth understanding of the mechanism of METTL14 in breast, digestive system and urinary system tumors is helpful to provide new clinical markers and drug targets for the prevention and treatment of tumors based on m 6A modification.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2022
Tipo de documento:
Artigo
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