Mucosal-associated Invariant T cells: A New Player in Innate Immunity
Journal of Rheumatic Diseases
;
: 337-345, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-95505
ABSTRACT
Mucosal-associated invariant T (MAIT) cells are evolutionarily conserved T cells that are restricted by the non-classical major histocompatibility complex class-1b molecule MR1. MAIT cells recognize riboflavin (vitamin B2) derivatives in a MR1-dependent manner. Following antigen recongnition, MAIT cells rapidly produce Th1/Th17 cytokines, such as interferon-gamma and interleukin-17, in an innate-like manner. MAIT cells maintain an activated phenotype throughout the course of an infection, secrete inflammatory cytokines, and have the potential to directly kill infected cells, thus, playing an important role in controlling the host response. In this review, we discuss current knowledge regarding the role of MAIT cells in infectious diseases, cancers, and autoimmune diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Riboflavina
/
Doenças Autoimunes
/
Linfócitos T
/
Doenças Transmissíveis
/
Citocinas
/
Interferon gama
/
Interleucina-17
/
Imunidade Inata
/
Complexo Principal de Histocompatibilidade
Idioma:
Inglês
Revista:
Journal of Rheumatic Diseases
Ano de publicação:
2015
Tipo de documento:
Artigo
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