Effect of peroxiredoxin 3 level before delivery on birth weight of offspring in patients with gestational diabetes mellitus / 中国医师进修杂志

ABSTRACT

Objective:To explore the correlation between peroxiredoxin 3 (PRX3) level before delivery and birth weight of offspring in patients with gestational diabetes mellitus (GDM).Methods:The clinical data of 126 primiparous women with GDM in Beijing Changping District Hospital from December 2019 to December 2020 were retrospectively analyzed. According to the birth weight of offspring, the patients were divided into macrosomia (newborn birth weight ≥4 000 g) group (32 cases) and non-macrosomia group (94 cases). Patient general data were recorded, and PRX3 levels were measured at 12, 20, 28, 32, 36, 38 and 39 weeks of gestation. The receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of PRX3 for birth weight of offspring in patients with GDM.Results:There were no statistical difference in age, body mass index before pregnancy, white blood cell, hemoglobin, lymphocyte, platelet, and the incidences of gestational anemia, premature rupture, malposition, fetal distress, oligohydramnios, placenta praevia between 2 groups ( P>0.05). The PRX3 12, 20, 28, 32, 36, 38, 39 weeks of gestation and birth weight of offspring in macrosomia group were significantly higher than those in non-macrosomia group (12.25 ± 2.36) μg/L vs. (10.11 ± 2.25) μg/L, (13.86 ± 2.33) μg/L vs. (11.95 ± 2.01) μg/L, (15.02 ± 2.58) μg/L vs. (12.69 ± 2.32) μg/L, (17.98 ± 3.69) μg/L vs. (14.79 ± 3.22) μg/L, (20.25 ± 2.94) μg/L vs. (16.55 ± 2.84) μg/L, (22.65 ± 3.88) μg/L vs. (18.06 ± 3.29) μg/L, (24.52 ± 3.59) μg/L vs. (19.57 ± 3.87) μg/L and (4 329.21 ± 300.58) g vs. (3 256.58 ± 330.47) g, and there were statistical differences ( P<0.01). According to the level of PRX3 before delivery, the patients with GDM were divided into high PRX3 group (71 cases, PRX3>20 μg/L) and low PRX3 group (55 cases, PRX3≤20 μg/L). The incidence of macrosomia in high PRX3 group was significantly higher than that in low PRX3 group 30.99% (22/71) vs. 18.18% (10/55), and there was statistical difference ( P<0.05). Pearson correlation analysis result showed that the birth weight of offspring was positive correlation with PRX3 level in patients with GDM ( r = 0.226, P = 0.001). ROC curve analysis result showed that the area under curve of PRX3 in predicting birth weight of offspring in patients with GDM was 0.865, with a sensitivity of 86.2%, a specificity of 79.8%, Yoden index of 0.660, and the optimal cut-off of 19.35 μg/L. Conclusions:The level of PRX3 is positively correlated with birth weight of offspring in patients with GDM.