Advances on mechanisms related to diabetic cardiomyopathy and mitophagy / 中华老年医学杂志

ABSTRACT

Diabetic cardiomyopathy(DCM)is a serious cardiovascular complication of diabetes.Mitochondrial dysfunction constitutes an important pathological basis of diabetic cardiomyopathy.Since DCM usually coexists with dysfunction of mitophagy, elucidating the relationship between them will help find new therapeutic targets for DCM.Mitochondrial autophagy includes two processes, the initiation of autophagy and degradation, and can selectively remove damaged mitochondria to achieve a balance in myocardial homeostasis and metabolic regulation in diabetes.Therefore, it is necessary to understand the role of mitochondrial autophagy in the pathophysiology underlying DCM, the influence of diabetes on mitochondria autophagy in cardiomyocytes and related molecular mechanisms.