Advances in immunoporosis / 中华内分泌代谢杂志

ABSTRACT

Osteoporosis is a common metabolic bone disease, which is involved in disrupted normal bone remodeling process and bone resorption exceeding bone formation. Osteoblasts and osteoclasts play critical roles in maintaining bone homeostasis. In recent years, more and more studies have found that immune cells are involved in the regulation of osteoblast and osteoclast activity via releasing various chemokines and cytokines, and the concept of immunoporosis has been proposed accordingly. This article summarizes the current state of knowledge on the immune system in the pathophysiology of osteoporosis, so as to study and prevent osteoporosis from the perspective of immunology.