Immune Stimulating Efficacy of Soluble beta-1,3-glucans
Immune Network
;
: 156-163, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-9577
ABSTRACT
BACKGROUND:
beta-1,3-glucans are well known to enhance the immune reactions, resulting in antitumor, antibacterial, antiviral, anticoagulatory and wound healing activities. beta-1, 3-glucans have various activities depending on molecular weight, degree of branching, conformation, water-solubility and intermolecular association. However, the beta-1,3-glucan linked backbone structure is essential and beta-D-glucopyranosyl units are required for immuno-potentiating activities.RESULT:
In this study, we tested the immunophamacological activities of soluble beta-1,3-glucans and confirmed the following activities (1) IFN-gamma production in PBMCs in the presence or the absence of PHA, LPS, or IL-18; (2) induction of various cytokines in the spleen and thymus; (3) adjuvant effect on the antibody production; (4) nitrogen oxide synthesis in macrophages; (5) the cytotoxic and antitumor effects on cell lines and ICR mice.CONCLUSION:
These results strongly suggested that beta-1,3-glucans possessed various immuno-pharmacological activities
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Baço
/
Timo
/
Cicatrização
/
Linhagem Celular
/
Citocinas
/
Interleucina-18
/
Macrófagos
/
Camundongos Endogâmicos ICR
/
Peso Molecular
/
Formação de Anticorpos
Limite:
Animais
Idioma:
Coreano
Revista:
Immune Network
Ano de publicação:
2003
Tipo de documento:
Artigo
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