Progress in complement receptor and co-inhibitory molecule VSIG4 / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 749-752, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-958252
ABSTRACT
V set and Ig domain containing 4 (VSIG4), a co-inhibitory molecule expressed by macrophages, is a B7 family-related protein. It can serve as the second signal of T cell activation and regulate the function of T cells. It has been found that VSIG4 is essential in maintaining immune tolerance. Moreover, VSIG4 can also act as a complement receptor, playing a role in recognizing pathogens, regulating the complement alternative pathway and inhibiting inflammatory response. This review summarized the expression of VSIG4 and its role in the immune system.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Microbiology and Immunology
Ano de publicação:
2022
Tipo de documento:
Artigo
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