Thinking and prospect of the application of flow cytometry in laboratory testing of chimeric antigen receptor T cell immunotherapy / 中华检验医学杂志

ABSTRACT

Chimeric antigen receptor (CAR)-T cell immunotherapy is one of the most remarkable achievements in the field of cancer therapy for the past few years. Flow cytometry (FCM) plays an important role in the design and construction of CAR-T cells, patient enrollment, performance test of CAR-T products, evaluation of post-treatment efficacy and immune function, exploration of relapse mechanism, and selection of subsequent treatment. In order to further promote and standardize the application of FCM in laboratory testing related to CAR-T cell immunotherapy, the special issue on "Application and Research Progress of flow cytometry in CAR-T cell immunotherapy" were organized by The Chinese Journal of Laboratory Medicine. A number of articles related to this topic were published, which covered expert consensus, continuing education, expert review, detection of minimal residual disease, immune function, and cytokine detection. We intend to promote the standardization of FCM in CAR-T cell immunotherapy and provide greater assistance for clinical application.