Value of hemagglutination indicators in the diagnosis of osteoporosis in patients with spinal degenerative diseases / 中华检验医学杂志

ABSTRACT

Objective:To explore the value of hemagglutination index in the diagnosis of osteoporosis in patients with spinal degenerative diseases.Methods:In this retrospective study, 313 patients with spinal degenerative diseases who were admitted to the Department of Spine Surgery of Beijing Jishuitan Hospital from November 2018 to April 2020 were selected and divided into osteoporosis group (119 cases), osteopenia group (101 cases) and normal group (93 cases) according to quantitative computed tomography (QCT) detection results. Fasting venous blood samples were taken to test coagulation indicators and bone turnover markers. One-way ANOVA or Kruskal-Wallis H tests were used to analyze the differences among three groups. The independent risk factors associated with Osteoporosis(OP)in patients with spinal degenerative diseases were screened from the blood indices. Furthermore, the osteopenia group and the normal group were combined into the non-osteoporosis group. Binary Logistic regression analysis was performed between the non-osteoporosis group and the osteoporosis group. Receiver operating curve (ROC) was used to evaluate the diagnostic value of relevant indicators in patients with spinal degenerative diseases.Results:Gender (χ 2=13.555, P=0.001), age ( F=17.53, P<0.001), Body Mass Index (BMI) ( F=4.068, P=0.018), β-C-terminal telopeptide of type I collagen (β-CTx) (χ 2=8.684, P=0.013), 25-hydroxyvitamin D [25(OH)D] (χ 2=6.155, P=0.046), D-dimer (χ 2=8.111, P=0.017) and platelet (PLT) ( F=6.809, P=0.001) were different significantly among three groups. The age ( P=0.006), D-dimer ( P=0.020) and PLT ( P=0.002) in normal group were remarkably lower than those in osteoporosis group. Age ( P<0.001) and PLT ( P=0.006) in osteopenia group were considerably lower than those in osteoporosis group, while β-CTX ( P=0.015) and BMI ( P=0.014) were significantly higher than those in osteoporosis group. The differences between non-osteoporosis group and osteoporosis group in gender, age, BMI, β-CTx, D-dimer and PLT were statistically significant (ALL P<0.05). Logistic regression showed that age [ OR=1.164, 95% CI (1.097-1.236)], gender [ OR=0.495, 95% CI (0.274-0.896)], BMI [ OR=0.890, 95% CI (0.816-0.971)] and PLT [ OR=1.008, 95% CI (1.003-1.103)] were independent risk factors for the osteoporosis group ( P<0.05). The AUCs (area under the curve) were detected separately by age AUC=0.715[95% CI (0.647-0.783)], gender AUC=0.612[95% CI (0.539-0.684)], BMI AUC=0.694[95%C I (0.622-0.766)], PLT AUC=0.610[95% CI (0.539-0.682)], and the combination of the former four indicators AUC=0.768[95% CI (0.706-0.829)] ( P<0.05). Conclusions:Based on the QCT results, the PLT count has considerable value in the diagnosis of osteoporosis in patients with spinal degenerative diseases. PLT combined with age, gender and BMI can greatly improve the diagnostic efficiency of osteoporosis.