Efficacy and safety of three-dimensional intraluminal post-loading radiotherapy in treatment of intermediate and advanced cervical cancer / 肿瘤研究与临床

ABSTRACT

Objective:To investigate the clinical efficacy and adverse reactions of 192Ir 3-dimensional intraluminal post-loading radiotherapy in treatment of locally middle and advanced cervical cancer. Methods:The clinical data of 100 middle and advanced cervical cancer patients in Shanxi Province Cancer Hospital from February 2018 to January 2021 were retrospectively analyzed, including 50 patients undergoing 192Ir 3-dimensional intraluminal post-loading radiotherapy (the 3D group) and 50 patients undergoing 192Ir 2-dimensional intraluminal post-loading radiotherapy (the 2D group). The therapeutic efficacy and adverse reactions of both groups were compared. Results:The objective response rate of the 3D group was higher than that of the 2D group, and the difference was statistically significant [98% (49/50) vs. 84% (42/50), χ2 = 4.40, P = 0.036]. The overall incidence of acute radioactive cystitis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [60% (30/50) vs. 88% (44/50), χ2 = 10.19, P = 0.003]. The incidence of grade 1 acute radiation cystitis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [26% (13/50) vs. 48% (24/50), χ2 = 5.19, P = 0.038]. The overall incidence of acute radiation enteritis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [68% (34/50) vs. 92% (46/50), χ2 = 9.00, P = 0.005]; the incidence of grade 2 and 3 acute radiation enteritis in the 3D group was lower than that in the 2D group, and the differences were statistically significant [28% (14/50) vs. 50% (25/50); 4% (2/50) vs. 20% (10/50), χ2 = 5.09, P = 0.040; χ2 = 6.06, P = 0.028]. The overall incidence of chronic radiation enteritis in the 3D group was lower than that in the 2D group, and the difference was statistically significant [28% (14/50) vs. 54% (27/50), χ2 = 6.99, P = 0.014]. Conclusions:Compared with 2-dimensional intraluminal post-loading radiotherapy, 3-dimensional intraluminal post-loading radiotherapy improves the efficacy of patients with intermediate and advanced cervical cancer, reduces the occurrence of acute and chronic radiation enteritis and radiation cystitis, reduces the adverse reactions of patients.