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Effect of different mydriatic regimens used for pupil dilation on the vital signs of premature infants for retinopathy of prematurity screening in a Philippine tertiary hospital: A randomized double-blind clinical trial
Acta Medica Philippina ; : 46-52, 2021.
Artigo em Inglês | WPRIM | ID: wpr-959987
ABSTRACT
@#<p style="text-align justify;"><strong>Objectives.</strong> To determine the safety and efficacy of three different mydriatic regimens in premature infants referred for retinopathy of prematurity (ROP) screening using (1) multiple alternate instillations of 0.5% cyclopentolate hydrochloride and 2.5% phenylephrine (MAI), (2) single instillation of 0.5%/0.5% tropicamide + phenylephrine (SI) and (3) single instillation of 0.5%/0.5% tropicamide + phenylephrine with a cotton wick placed in the inferior fornix (SIW) in a Philippine tertiary hospital.</p><p style="text-align justify;"><strong>Methods.</strong> A randomized, double-blind, clinical trial included preterm infants for ROP screening at a Philippine tertiary hospital. After instillations via MAI, SI, and SIW, systolic blood pressure (SBP), diastolic pressure (DBP), mean arterial pressure (MAP), heart rate, and oxygen saturation were monitored. Pupillary dilation was also measured.</p><p style="text-align justify;"><strong>Results.</strong> Sixty preterm infants, 20 to each intervention, were included. The MAI group did not have significant changes relative to its baseline vital signs. The use of SI produced lower DBP (p<0.0106) and MAP (p<0.0027) compared to MAI. The use of SI produced lower DBP (p<0.01) and MAP (p<0.003) compared to MAI. The SIW group exhibited significant increases in SBP (p<0.002) and in MAP (p<0.04) compared to MAI. This increase in SBP exceeded the clinical normal values for <37 weeks old infants. Pupillary dilation did not have significant differences among groups (p=0.24).</p><p style="text-align justify;"><strong>Conclusion.</strong> Due to significant increase in SBP, it is recommended to discontinue SIW in preterm infants for ROP screening since it may promote the mydriatic's systemic absorption. Except for the clinically increased heart rate in infants aged ?37 weeks at examination, SI was found to be at par with the recommendation of the UK ROP Guidelines of May 2008.</p>
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ROP
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Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenilefrina / Tropicamida / Retinopatia da Prematuridade / Recém-Nascido Prematuro / Programas de Rastreamento / Ciclopentolato / Nascimento Prematuro Idioma: Inglês Revista: Acta Medica Philippina Ano de publicação: 2021 Tipo de documento: Artigo

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Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenilefrina / Tropicamida / Retinopatia da Prematuridade / Recém-Nascido Prematuro / Programas de Rastreamento / Ciclopentolato / Nascimento Prematuro Idioma: Inglês Revista: Acta Medica Philippina Ano de publicação: 2021 Tipo de documento: Artigo