Antitumor of Main Active Components of Poria： A Review / 中国实验方剂学杂志

ABSTRACT

ObjectiveMalignant tumor has become a serious public health problem， threatening human health. Chinese herbal medicine has become a research focus as it is "simple， convenient， inexpensive， and effective" and exerts anti-tumor effect through "multiple components， multiple targets， and multiple pathways". This paper reviews the anti-tumor effect of triterpenes， polysaccharides and other compounds in Poria， which is expected to serve as a reference for research on the anti-tumor effect of Poria. MethodBasic research， clinical observation， and reviews were retrieved from PubMed， Google Scholar， and China National Knowledge Infrastructure （CNKI） （1995—2022） with the keywords of Poria and malignant tumor. ResultThe main active components of Poria such as triterpenes represented by pachymic acid and polysaccharides represented by pachyman had extensive pharmacological effects in inhibiting the proliferation of malignant tumors， inducing apoptosis， suppressing invasion and metastasis， regulating the immune function， and improving the quality of life. In addition， the cultivation method， medicinal part， growth environment， and harvest cycle of the medicinal plant， and dosage form and processing method of Poria affected the content of different active components. ConclusionThe active components of pachymic acid and triterpenoids have great potential in antitumor， which， however， face the challenges in innovation and quality clinical trials. The lack of quality control standard of Poria may affect the anti-tumor effect， and efforts should be made to formulate specific standard for quality control. The antitumor of Poria is science-based and thus it has broad application prospect. Nevertheless， more efforts should be made before the practical application.