Levothyroxine versus levothyroxine with iodine in reduction of thyroid nodule volume: a double-blind randomized controlled trial
Philippine Journal of Otolaryngology Head and Neck Surgery
;
: 14-19, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-961053
ABSTRACT
@#<p><strong>Objective:
</strong>To compare levothyroxine alone and in combination with iodine on thyroid nodule volume reduction.</p><p><strong>Methods:
</strong></p><p><strong>Design:
</strong>Double-Blind Randomized Controlled Trial</p><p><strong>Setting:
</strong>Tertiary Government Hospital</p><p><strong>Participants:
</strong>Nineteen (19) euthyroid patients age 19-54 with at least 1 cytologically benign thyroid nodule were randomized to receive either levothyroxine + iodine or levothyroxine + placebo, taken once a day for 6 months with ultrasound and thyroid stimulating hormone monitoring on the 3rd and 6th month of intervention.</p><p><strong>Results:
</strong>Main outcome measures included thyroid nodule volume reduction after six months of intervention. The mean change in volume from baseline to six months of levothyroxine + iodine group showed no statistically significant difference in nodule volume across time between levothyroxine + placebo group, -0.010 ± 1.250 (CI -0.521 - 0.501) versus 0.507 ± 1.128 (CI 0.025 - 0.990), p=.158. There were also new nodules (4 nodules) in the placebo group and none in the iodine group. No major adverse events were noted during the study.</p><p><strong>Conclusion:
</strong>The two groups did not significantly differ in terms of nodule volume reduction.</p><p><strong>Keywords</strong> thyroid nodule, prevention and control; drug therapy; iodine compounds, therapeutic use; levothyroxine, therapeutic use</p>
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tiroxina
/
Nódulo da Glândula Tireoide
/
Compostos de Iodo
/
Tratamento Farmacológico
Limite:
Humanos
Idioma:
Inglês
Revista:
Philippine Journal of Otolaryngology Head and Neck Surgery
Ano de publicação:
2019
Tipo de documento:
Artigo
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