Mean Hematocrit values, disease severity, and discharge status of undernourished versus well-nourished children with Dengue Infection in a tertiary government hospital

ABSTRACT

Background@#Studies comparing hematocrit values, disease severity, and discharge status between well-nourished and undernourished pediatric dengue patients are limited. @*Objective@#This study compared the mean hematocrit values, disease severity and discharge status of undernourished vs. well-nourished pediatric dengue patients admitted in a tertiary government hospital. @*Methodology@#A retrospective cohort study involving 114 pediatric dengue patients, with comparison groups of well-nourished and undernourished children matched according to age, phase of illness and sex was done. Main outcomes measured were mean hematocrit values, disease severity and discharge status.@*Results@#There was a significantly lower mean pre-resuscitation hematocrit in the wasted (M=39.67%, SD=3.78) compared to the well-nourished group (M=43.68%, SD=4.72), p=0.006, among children >6 to 12 years old in the febrile phase. There were no significant differences in disease severity and discharge status between wasted and well-nourished children. In those >2 to 6 years old in the febrile phase, the severely wasted had significantly higher pre-resuscitation hematocrit (M=43.28%, SD=4.77) compared to well-nourished children (M=39.11%, SD=5.34), p=0.041. More severe dengue, worse discharge status and an earlier time to demise was seen among severely wasted children. @*Conclusion@#Wasted participants had significantly lower mean hematocrit values with no difference in diseaseseverity and discharge status when compared to well-nourished participants. Severely wasted children had significantly higher hematocrit values, severe dengue, and worse discharge status.