Enzymatic debridement of corneal ulcers with fibrinolysin and desoxyribonuclease

ABSTRACT

1. Fibrinolysin and DNAase can effectively debride the necrotic tissue in artificially produced rabbit corneal ulcers without injuring the non-necrotic, viable portion of the cornea2. By comparing the treated and untreated bacterial and chemical corneal ulcers in rabbits, there was noted generally less inflammatory reaction and a faster and better healing in those where enzymatic debridement were done3. The basis for the clinical use of enzymatic debridement of corneal ulcers by fibrinolysin and DNAase has been amply demonstrated. (Summary and conclusions)