Results of further experimental studies on BCG vaccine

ABSTRACT

In a series of experiments on 41 monkeys preliminarily reported in 1934 it was found that no return of virulence of BCG developed during a period of about two (2) years observation. These findings seem to corroborate Calmettes claim that BCG is a fixed virus and can be used for human purposesIn another series of experiments with twenty-three (23) monkeys in which parenteral routes of vaccination with BCG were used, the subcutaneous route gave more protection than the intradermal. For subcutaneous injection a smaller amount was used. It was attended by less local and glandular involvement and the animals lived longer after the administration of an infective dose of living virulent human tubercle bacilli by any route (intraperitoneal intratracheal, or subcutaneous). (Conclusion)