Effects of Morroniside on IL-1β in Rat Cortex with Focal Cerebral Ischemia/Reperfusion / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 928-930, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-964176
ABSTRACT
@#ObjectiveTo investigate the effects of morroniside on IL-1β in rat cortex with focal cerebral ischemia/reperfusion.MethodsThe animal model was induced by occlusion of middle cerebral artery with suture embolus, ischemia for 30 min, and reperfusion for 72 h in rats. The content of IL-1β was detected with enzyme linked immunosorbent assay(ELISA).ResultsCompared with sham group, the content of IL-1β increased obviously in model rat. Compared with model group, morroniside(30 mg/kg, 90 mg/kg, 270 mg/kg) and colchicine (0.06 mg/kg) decreased the content of IL-1β significantly (P<0.001).ConclusionMorroniside may protect the cortex from inflammatory factor IL-1β.
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Ano de publicação:
2010
Tipo de documento:
Artigo
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