Association of metabolic syndrome with different phenotypes of polycystic ovarian syndrome among Filipino women in a tertiary hospital: A retrospective cohort study / Philippine Journal of Obstetrics and Gynecology

ABSTRACT

Introduction@#Polycystic ovarian syndrome (PCOS) is a common endocrinopathy affecting women during reproductive age. Women affected by PCOS generally have a higher risk of developing Metabolic syndrome (MetS). MetS on each phenotype of PCOS reflects some phenotypes with worse metabolic profiles and a higher risk of developing long-term complications in women with PCOS.@*Objective@#To determine the association of MetS with different phenotypes of PCOS among Filipino women in a tertiary hospital.@*Materials and Methods@#This is a retrospective cohort study of 154 women in a tertiary hospital, both private and service divisions@*Results@#A total of 154 patients with PCOS were analyzed in this study 67 (43.51%) Phenotype A, 25 (16.23%) Phenotype B, 3 (1.95%) Phenotype C, and 59 (38.31%) phenotype D. The prevalence of MetS in PCOS was 69.48%, with no significant difference statistically between phenotypes. MetS was most prevalent in Phenotype A (74.63%) and least prevalent in phenotype D (62.71%). Among Filipino women with PCOS, Phenotype A had a 2.5 times increased risk of developing MetS compared to Phenotype D.@*Conclusion@#Phenotype A is the most common phenotype and has the highest prevalence in developing metabolic changes. Increasing body mass index and age played significant roles in elevating the risk of developing MetS. Early detection of MetS in all phenotypes of PCOS can aid in preventing the development of long-term complications such as cardiovascular disease and diabetes mellitus type II.