Variation in oxidative injury markers in workers with occupationalnoise-induced hearing loss / 中国职业医学
China Occupational Medicine
; (6): 292-2022.
Article
em Zh
| WPRIM
| ID: wpr-965169
Biblioteca responsável:
WPRO
ABSTRACT
@#Abstract: Objective - To explore the changes of oxidative damage indicators in workers with occupational noise induced ( ), Methods hearingloss ONHL andtoscreenpossiblebiomarkersofONHL. Atotalof288maleworkersexposedtonoisein a large machinery maintenance enterprise were selected as the research subjects using the method of judgment sampling. After , pure tone hearing threshold test they were divided into hearing loss group and normal hearing group according to the hearing ∶ , , , loss and 1 1 pairing design of type of work age length of service with 144 people in each group. The activities of total ( - ), - ( - ), ( - ), superoxidedismutase T SOD copper zincsuperoxidedismutase CuZn SOD manganesesuperoxidedismutase Mn SOD - ( ) ( ) Results glutathione S transferase GST and catalase CAT in serum of workers of the two groups were measured. The , - , - activitiesofGST T SOD Mn SOD and CAT in workersofthe hearing lossgroup were lowerthan those in the normalhearing ( P< ) ∶ group all 0.05 . The 1 1 logistic regression analysis of paired conditions showed that there was an association between , - , ( P< ) ONHL and activities of GST Mn SOD and CAT in serum all 0.05 after controlling the effects of smoking and drinking. , - , - ThehighertheactivitiesofGST Mn SODandCAT thelowertheriskofONHL.TheactivityofCuZn SODwasnotassociated (P )Conclusion , - withONHL >0.05 . TheactivitiesofserumantioxidantenzymessuchasGST Mn SODandCATarerelatedto ONHL.ThoseantioxidantenzymescanbeusedaseffectivebiomarkersforONHLworkers.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
China Occupational Medicine
Ano de publicação:
2022
Tipo de documento:
Article