Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+ T Cell Activity
Immune Network
;
: 126-134, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-96923
ABSTRACT
BACKGROUND:
CD8+ T cells contribute to the clearance of Hepatitis B virus (HBV) infection and an insufficient CD8+ T cell response may be one of the major factors leading to chronic HBV infection. Since the HBx antigen of HBV can up-regulate cellular expression of several immunomodulatory molecules, we hypothesized that HBx expression in hepatocytes might affect CD8+ T cell activity.METHODS:
We analyzed the activation and apoptosis of CD8+ T cells co-cultured with primary hepatocytes rendered capable of expressing HBx by recombinant baculovirus infection.RESULTS:
Expression of HBx in hepatocytes induced low production of interferon-gamma and apoptosis of CD8+ T cells, with no effect on CD8 T cell proliferation. However, transcriptional levels of H-2K, ICAM-1 and PD-1 ligand did not correlate with HBx expression in hepatocytes.CONCLUSION:
Our results suggest that HBx may inhibit CD8+ T cell response by regulation of interferon-gamma production and apoptosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas Virais
/
Linfócitos T
/
Hepadnaviridae
/
Transativadores
/
Vírus da Hepatite B
/
Baculoviridae
/
Interferon gama
/
Apoptose
/
Molécula 1 de Adesão Intercelular
/
Hepatócitos
Idioma:
Inglês
Revista:
Immune Network
Ano de publicação:
2010
Tipo de documento:
Artigo
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