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Application of emerging technologies for gut microbiome research
Singapore medical journal ; : 45-52, 2023.
Artigo em Inglês | WPRIM | ID: wpr-969664
ABSTRACT
Microbiome is associated with a wide range of diseases. The gut microbiome is also a dynamic reflection of health status, which can be modified, thus representing great potential to exploit the mechanisms that influence human physiology. Recent years have seen a dramatic rise in gut microbiome studies, which has been enabled by the rapidly evolving high-throughput sequencing methods (i.e. 16S rRNA sequencing and shotgun sequencing). As the emerging technologies for microbiome research continue to evolve (i.e. metatranscriptomics, metabolomics, culturomics, synthetic biology), microbiome research has moved beyond phylogenetic descriptions and towards mechanistic analyses. In this review, we highlight different approaches to study the microbiome, in particular, the current limitations and future promise of these techniques. This review aims to provide clinicians with a framework for studying the microbiome, as well as to accelerate the adoption of these techniques in clinical practice.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Filogenia / RNA Ribossômico 16S / Nível de Saúde / Microbioma Gastrointestinal Limite: Humanos Idioma: Inglês Revista: Singapore medical journal Ano de publicação: 2023 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Filogenia / RNA Ribossômico 16S / Nível de Saúde / Microbioma Gastrointestinal Limite: Humanos Idioma: Inglês Revista: Singapore medical journal Ano de publicação: 2023 Tipo de documento: Artigo