Latent period and incubation period with associated factors of COVID-19 caused by Omicron variant / 中华预防医学杂志

ABSTRACT

Objective: To estimate the latent period and incubation period of Omicron variant infections and analyze associated factors. Methods: From January 1 to June 30, 2022, 467 infected persons and 335 confirmed cases in five local Omicron variant outbreaks in China were selected as the study subjects. The latent period and incubation period were estimated by using log-normal distribution and gamma distribution models, and the associated factors were analyzed by using the accelerated failure time model (AFT). Results: The median (Q1, Q3) age of 467 Omicron infections including 253 males (54.18%) was 26 (20, 39) years old. There were 132 asymptomatic infections (28.27%) and 335 (71.73%) symptomatic infections. The mean latent period of 467 Omicron infections was 2.65 (95%CI 2.53-2.78) days, and 98% of infections were positive for nucleic acid detection within 6.37 (95%CI 5.86-6.82) days after infection. The mean incubation period of 335 symptomatic infections was 3.40 (95%CI 3.25-3.57) days, and 97% of them developed clinical symptoms within 6.80 (95%CI 6.34-7.22) days after infection. The results of the AFT model analysis showed that compared with the group aged 18~49 years old, the latent period [exp(β)=1.36 (95%CI 1.16-1.60), P<0.001] and incubation period [exp(β)=1.24 (95%CI 1.07-1.45), P=0.006] of infections aged 0~17 year old were also prolonged. The latent period [exp(β)=1.38 (95%CI 1.17-1.63), P<0.001] and the incubation period [exp(β)=1.26 (95%CI 1.06-1.48), P=0.007] of infections aged 50 years old and above were also prolonged. Conclusion: The latent period and incubation period of most Omicron infections are within 7 days, and age may be the influencing factor of the latent period and incubation period.