New mechanisms of chronic kidney disease-associated vascular calcification / 生理学报
Acta Physiologica Sinica
;
(6): 913-926, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-970087
ABSTRACT
Vascular calcification is the crucial factor of high cardiovascular disease morbidity and mortality in patients with chronic kidney disease (CKD), which causes a huge medical and economic burden. It is urgent to explore its pathogenesis and intervention methods. CKD-associated vascular calcification is an ectopic osteogenesis process actively regulated by multiple cells. Vascular smooth muscle cells (VSMCs) undergo osteogenic differentiation in a pro-calcification environment, and secrete matrix vesicles to form calcium and phosphorus crystal deposition sites, which are key events in the development of CKD-associated vascular calcification. This article reviews the new mechanism and technology of CKD-associated vascular calcification and discusses the role of the myokine Irisin in CKD-associated vascular calcification.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Doenças Cardiovasculares
/
Proteínas
/
Progressão da Doença
/
Miócitos de Músculo Liso
/
Insuficiência Renal Crônica
/
Calcificação Vascular
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2022
Tipo de documento:
Artigo
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