Therapeutic potential of targeting SIRT1 for the treatment of Alzheimer's disease / 生理学报
Acta Physiologica Sinica
;
(6): 99-107, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-970110
ABSTRACT
Silent information regulator 1 (SIRT1) is one of the seven mammalian proteins of the sirtuin family of NAD+-dependent deacetylases. SIRT1 plays a pivotal role in neuroprotection and ongoing research has uncovered a mechanism by which SIRT1 may exert a neuroprotective effect on Alzheimer's disease (AD). Growing evidence demonstrates that SIRT1 regulates many pathological processes including amyloid-β precursor protein (APP) processing, neuroinflammation, neurodegeneration, and mitochondrial dysfunction. SIRT1 has recently received enormous attention, and pharmacological or transgenic approaches to activate the sirtuin pathway have shown promising results in the experimental models of AD. In the present review, we delineate the role of SIRT1 in AD from a disease-centered perspective and provides an up-to-date overview of the SIRT1 modulators and their potential as effective therapeutics in AD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Animais Geneticamente Modificados
/
Precursor de Proteína beta-Amiloide
/
Sirtuínas
/
Sirtuína 1
/
Doença de Alzheimer
Limite:
Animais
/
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2023
Tipo de documento:
Artigo
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