Principle and development of single base editing technology and its application in livestock breeding / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 19-33, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-970356
ABSTRACT
CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein) is widely used in the field of livestock breeding. However, its low efficiency, untargeted cutting and low safety have greatly hampered its use for introducing single base mutations in livestock breeding. Single base editing, as a new gene editing tool, can directly replace bases without introducing double strand breaks. Single base editing shows high efficiency and strong specificity, and provides a simpler and more effective method for precise gene modification in livestock breeding. This paper introduces the principle and development of single base editing technology and its application in livestock breeding.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tecnologia
/
Gado
/
Sistemas CRISPR-Cas
/
Edição de Genes
/
Mutação
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2023
Tipo de documento:
Artigo
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