Progress on the design and optimization of antimicrobial peptides / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1247-1253, 2022.
Artigo
em Chinês
| WPRIM
| ID: wpr-970664
ABSTRACT
Antimicrobial peptides (AMPs) are a class of peptides widely existing in nature with broad-spectrum antimicrobial activity. It is considered as a new alternative to traditional antibiotics because of its unique mechanism of antimicrobial activity. The development and application of natural AMPs are limited due to their drawbacks such as low antimicrobial activity and unstable metabolism. Therefore, the design and optimization of derived peptides based on natural antimicrobial peptides have become recent research hotspots. In this paper, we focus on ribosomal AMPs and summarize the design and optimization strategies of some related derived peptides, which include reasonable primary structure modification, cyclization strategy and computer-aided strategy. We expect to provide ideas for the design and optimization of antimicrobial peptides and the development of anti-infective drugs through analysis and summary in this paper.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Desenho de Fármacos
/
Peptídeos Catiônicos Antimicrobianos
/
Peptídeos Antimicrobianos
/
Anti-Infecciosos
/
Antibacterianos
Idioma:
Chinês
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2022
Tipo de documento:
Artigo
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