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The Effect of Vitamin E and N-acetyl-cysteine in Amiodarone-induced Pulmonary Fibrosis in Hamsters
Journal of the Korean Society of Emergency Medicine ; : 71-77, 2003.
Artigo em Coreano | WPRIM | ID: wpr-97133
ABSTRACT

PURPOSE:

Amiodarone (AD) is a potent and effective anti-dysrhythmic drug, but some literature reports that it 's long-term use is associated with the development of potentially life-threatening amiodarone-induced pulmonary toxicity (AIPT). Until now, oxygen free radical theory has been the most probable hypothesis for the development of AIPT. We investigated the protective effect of two potent antioxidants, N-acetylcysteine(NAC) and vitamin E, against AIPT.

METHODS:

Twenty-six (26) Hamsters were divided into a sham-operation group(n=2) and the following 4 groups AD-induced effects without antioxidants (group 1, n=6), with NAC (group 2, n=6), with vitamin E (group 3, n=6), and with both NAC and vitamin E (group 4, n=6). Vitamin E (100 mg/kg) was injected intramuscularly into the hind leg once a day. At day 21, amiodarone (1.83 umol) was administered by transoral intratracheal instillation. NAC (300 mg/kg) was injected intraperitoneally just after amiodarone instillation. At day 28, amiodarone and NAC were administered again. Twenty-one (21) days after instillation of the second dose of amiodarone, the hamsters were sacrificed, and the lung fibrosis index and the hydroxyproline content were assessed.

RESULTS:

In the NAC-treated group (group 2), there was no significant decrease in either the lung fibrosis index, as determined by microscopic evaluation, or the lung hydrox-yproline content (p > 0.05). But there were significant decreases in the fibrosis index and the lung hydroxyproline content in the vitamin E-treated groups (group 3 and 4 ) (p < 0.05).

CONCLUSION:

Although vitamin E and NAC are both potent antioxidants, we found that AD-induced lung fibrosis was significantly decreased by only vitamin E and that there was no synergistic effect between vitamin E and NAC. It is possible that AIPT is developed by some other mechanisms rather than oxygen free radical injury. Vitamin E may have some other path for decreasing lung fibrosis. Further studies are warranted.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oxigênio / Acetilcisteína / Fibrose Pulmonar / Vitamina E / Vitaminas / Fibrose / Amiodarona / Hidroxiprolina / Perna (Membro) / Pulmão Limite: Animais Idioma: Coreano Revista: Journal of the Korean Society of Emergency Medicine Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Oxigênio / Acetilcisteína / Fibrose Pulmonar / Vitamina E / Vitaminas / Fibrose / Amiodarona / Hidroxiprolina / Perna (Membro) / Pulmão Limite: Animais Idioma: Coreano Revista: Journal of the Korean Society of Emergency Medicine Ano de publicação: 2003 Tipo de documento: Artigo