Parkinson's Disease: A Multisystem Disorder / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 113-124, 2023.
Artigo
em Inglês
| WPRIM
| ID: wpr-971556
ABSTRACT
The way sporadic Parkinson's disease (PD) is perceived has undergone drastic changes in recent decades. For a long time, PD was considered a brain disease characterized by motor disturbances; however, the identification of several risk factors and the hypothesis that PD has a gastrointestinal onset have shed additional light. Today, after recognition of prodromal non-motor symptoms and the pathological processes driving their evolution, there is a greater understanding of the involvement of other organ systems. For this reason, PD is increasingly seen as a multiorgan and multisystemic pathology that arises from the interaction of susceptible genetic factors with a challenging environment during aging-related decline.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Fatores de Risco
/
Trato Gastrointestinal
/
Alfa-Sinucleína
/
Sintomas Prodrômicos
/
Microbioma Gastrointestinal
Limite:
Humanos
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2023
Tipo de documento:
Artigo
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