Glia Connect Inflammation and Neurodegeneration in Multiple Sclerosis / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 466-478, 2023.
Artigo
em Inglês
| WPRIM
| ID: wpr-971586
ABSTRACT
Multiple sclerosis (MS) is regarded as a chronic inflammatory disease that leads to demyelination and eventually to neurodegeneration. Activation of innate immune cells and other inflammatory cells in the brain and spinal cord of people with MS has been well described. However, with the innovation of technology in glial cell research, we have a deep understanding of the mechanisms of glial cells connecting inflammation and neurodegeneration in MS. In this review, we focus on the role of glial cells, including microglia, astrocytes, and oligodendrocytes, in the pathogenesis of MS. We mainly focus on the connection between glial cells and immune cells in the process of axonal damage and demyelinating neuron loss.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Medula Espinal
/
Encéfalo
/
Neuroglia
/
Inflamação
/
Esclerose Múltipla
Limite:
Humanos
Idioma:
Inglês
Revista:
Neuroscience Bulletin
Ano de publicação:
2023
Tipo de documento:
Artigo
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