Analysis of chromosome aberration and micronucleus frequencies in 102 patients with cancer before and after radiotherapy and chemotherapy / 中国辐射卫生

ABSTRACT

@#<b>Objective</b> To investigate the changes of chromosome aberration and micronucleus frequencies in the peripheral blood of patients with cancer before and after treatment, and to provide a basis for clinical prevention and treatment. <b>Methods</b> We collected the physical examination data of 102 patients with cancer before and after treatment from 2016 to 2021 to analyze the changes of chromosome aberration and micronucleus frequencies in peripheral blood. <b>Results</b> Before and after treatment, there were significant differences in chromosome aberration frequency and micronucleus frequency in peripheral blood lymphocytes in patients having radiotherapy or chemoradiotherapy (all <i>P</i> < 0.05), but no significant difference was observed in either index for patients having chemotherapy (both <i>P</i> > 0.05). Before and after radiotherapy, there were significant differences in the numbers of patients with abnormal chromosome aberration frequency and those with abnormal micronucleus frequency in lymphocytes (both <i>P</i> < 0.001). Before and after chemotherapy, there was no significant difference in the number of patients with abnormal chromosome aberration frequency (<i>P</i> = 0.100) or those with abnormal micronucleus frequency (<i>P</i> = 0.110). <b>Conclusion</b> Radiotherapy can cause abnormalities in chromosome aberration and micronucleus frequencies in peripheral blood lymphocytes, which can be useful for monitoring radiotherapy injury to formulate effective emergency plans and evaluate radiation dose in each course of treatment.