Factors for poor prognosis of near-fatal asthma after recovery from a life-threatening asthma attack
The Korean Journal of Internal Medicine
;
: 170-175, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-97389
ABSTRACT
BACKGROUND/AIMS:
The aim of this study was to investigate poor prognostic factors associated with a near-fatal asthma attack following patient recovery.METHODS:
We enrolled 68 patients who suffered near-fatal asthma attacks and were admitted to the intensive care units of five university hospitals. The patients were divided into two groups. The first group was comprised of patients who discontinued oral corticosteroids within 6 months after being discharged from the hospital and who maintained a forced expiratory volume in 1 s (FEV1) > or =60% of the maximum or estimated values of the corresponding patients. The second group included patients who continued on oral corticosteroids for > or =6 months or who maintained a FEV1 <60%.RESULTS:
In patients with near-fatal asthma, factors for a poor prognosis included older age [48.47+/-3.53 vs. 64.69+/-2.59 years, p<0.05], chronic severe asthma, high values for inflammation-related laboratory markers (ESR, 8.75+/-2.05 vs. 23.88+/-4.40 mm/h, p=0.004; CRP, 1.72+/-0.46 vs. 6.68+/-9.36 mg/dL, p<0.05), asthma exacerbated by pneumonia (28.1 vs. 52.8%, p<0.05), and relatively low nutritional status (albumin, 4.00+/-0.14 vs. 3.51+/-0.10 g/dL, p<0.05).CONCLUSIONS:
These prognostic factors may induce irreversible obstruction of the airways with subsequent acute exacerbation of asthma or the need for continual oral corticosteroids after being discharged from the hospital. Patients with these factors should be treated appropriately, under close surveillance.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Asma
/
Volume Expiratório Forçado
/
Fatores de Risco
/
Estudos de Coortes
/
Recuperação de Função Fisiológica
/
Morte
/
Glucocorticoides
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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