Pathogenic mechanism of Acinetobacter baumannii and research status of corresponding vaccines / 中国生物制品学杂志

ABSTRACT

@#As a Gram-negative bacillus,Acinetobacter baumannii is one of the main opportunistic pathogens causing nosocomial infection,and mainly infects various human organs such as lungs,which finally causes bacteremia,pneumonia and other diseases,and seriously threatens lives of patients.People with weak immunity are the main susceptible people.The strain has strong stress resistance and multiple antibiotic resistance,making its infection a difficult problem in clinical treatment.The outer membrane complex(OMC),outer membrane vesicles(OMVs),secretory system and lipopolysaccharide of A.baumannii play an important role in the process of infection of host cells.At present,the vaccines developed against these pathogenic components can play a certain role in preventing and treating A.baumannii infection,and have a good application prospect.In this paper,the pathogenesis of A.baumannii and the current situation of vaccine development are reviewed,so as to provide a reference for the development of novel prevention and treatment methods of it in clinic.