Subchronic Inhalation Toxicity Study of n-pentane in Rats
Safety and Health at Work
;
: 224-234, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-97541
ABSTRACT
OBJECTIVES:
This study was conducted in order to obtain information concerning the health hazards that may result from a 13 week inhalation exposure of n-pentane in Sprague-Dawley rats.METHODS:
This study was conducted in accordance with the Organization for Economic Co-operation and Development (OECD) guidelines for the testing of chemicals No. 413 'Subchronic inhalation toxicity 90-day study (as revised in 2009)'. The rats were divided into 4 groups (10 male and 10 female rats in each group), and were exposed to 0, 340, 1,530, and 6,885 ppm n-pentane in each exposure chamber for 6 hour/day, 5 days/week, for 13 weeks. All of the rats were sacrificed at the end of the treatment period. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, locomotion activity, urinalysis, hematology, serum biochemistry, gross findings, organ weights, and histopathology were assessed.RESULTS:
During the period of testing, there were no treatment related effects on the clinical findings, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, relative organ weight, and histopathological findings.CONCLUSION:
The no-observable-adverse-effect level (NOAEL) of n-pentane is evaluated as being more than 6,885 ppm (20.3 mg/L) in both male and female rats. n-pentane was not a classified specific target organ toxicity in the globally harmonized classification system (GHS).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oftalmoscopia
/
Tamanho do Órgão
/
Pentanos
/
Bioquímica
/
Peso Corporal
/
Substâncias Perigosas
/
Inalação
/
Urinálise
/
Ratos Sprague-Dawley
/
Exposição por Inalação
Tipo de estudo:
Guia de Prática Clínica
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Safety and Health at Work
Ano de publicação:
2012
Tipo de documento:
Artigo
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