Adiponectin level in aging male of Mongolia / Монголын Анагаах Ухаан

ABSTRACT

INTRODUCTION: Adipose tissue exclusively secretes adiponectin, a 244–amino-acid protein that regulates themetabolism of lipids and glucose and circulates quite abundantly in plasma. Adiponectin were still stronglyassociated with an increased diabetes risk in men; but the association for women was no longer statisticallysignificant. Adiponectin decreases insulin resistance and body weight by increasing lipid oxidation in muscleand other organs such as the pancreas and liver.GOAL: To define of adiponectin level in aging man living in Ulaanbaatar city.MATERIALS AND METHODS: Randomly selected 84 men aged 35-90 years old were involved to this study. Veinblood were collected, the serum were separated and were frozen until assayed by immunosorbent assay.Morning baseline adiponectin were determined in the sera. We used ELISA kit from Mesdia company (Korea).RESULT AND DISCUSSION: Average age of all participants was 56.82±12.55 years and was divided in three agegroups: 35-60 (31.1%), 61-74 (10%), 74-90 (5.55%). Levels of adiponectin were inversely associated with BMI(r=-0.103), WC (r=-0.173), and TG (r=0.143) and directly associated with age and HDL-C (r=0.117, p<0.001).All people were divided by NCEP criteria in two groups: metabolic syndrome group and healthy control group.Average adiponectin level in metabolic syndrome group was 4.83±7.10 ug/ml, in healthy group it was 5.71±7.53ug/ml, which shows that adiponectin level is significantly lower in people with metabolic syndrome.CONCLUSION: Adiponectin level was lower in people with metabolic syndrome and it has inverse correlation withwaist circumference.