Radio-protective effect of sulfated polysaccharide purified from Ecklonia cava against small intestinal stem cells of gamma-ray irradiated mice / 동물의과학연구지
Journal of Biomedical Research
;
: 220-225, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-97585
ABSTRACT
Our previous research on sulfated polysaccharide purified from Ecklonia cava, a brown alga found in Jeju island, Korea, showed that sulfated polysaccharides modulate the apoptotic threshold of intestinal cells, thereby preventing intestinal damage caused by ionizing radiation. In this study, we investigated the ability of sulfated polysaccharide to augment restoration of small intestinal stem cells from gamma-ray-induced damage. In our results, sulfated polysaccharide treatment increased the numbers of Ki-67-positive cells as well as inducible nitric oxide synthase (iNOS)-expressing cells in the small intestine compared with those of irradiated only mice. Meanwhile, exposure to irradiation increased the number of paneth cells, which are frequently associated with intestinal inflammation, whereas sulfated polysaccharide treatment reduced the number of paneth cells in the small intestinal crypt. Conclusively, our data suggest that reduction of iNOS-expressing cells and paneth cells in sulfated polysaccharide-treated mice contributes to the inhibition of radiation-induced intestinal inflammation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polissacarídeos
/
Radiação Ionizante
/
Células-Tronco
/
Celulas de Paneth
/
Óxido Nítrico Sintase Tipo II
/
Inflamação
/
Intestino Delgado
/
Coreia (Geográfico)
Limite:
Animais
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of Biomedical Research
Ano de publicação:
2013
Tipo de documento:
Artigo
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