Research progress about TyK2 inhibitor deucravacitinib for the treatment of systemic lupus erythematosus / 中国药房
China Pharmacy
;
(12): 1529-1531, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-976283
ABSTRACT
Deucravacitinib is a selective tyrosine kinase 2 inhibitor. It has shown certain therapeutic potential for various immune system diseases, and its use in systemic lupus erythematosus (SLE) is currently in the clinical trial stage. Deucavacitinib is easily absorbed by oral administration and can cause pharmacological effects within 24 hours. Compared with placebo, after 32 weeks of treatment, patients in the deucravacitinib group who meet the SLE response index 4 have a higher proportion, and a higher response rate in the British Isles Lupus Assessment Group’s comprehensive lupus assessment, cutaneous lupus erythematosus disease area and severity index of 50, low disease activity status, and activity, swelling, and tenderness joint counts. In terms of safety, the incidence of adverse events such as rash and acne is higher in the deucravacitinib group than placebo group, but further observation was still needed. At present, more studies are evaluating the cost-effectiveness and safety of deucravatinib in the treatment of SLE, with the expectation of more data validation of deucravatinib’s therapeutic potential.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacy
Ano de publicação:
2023
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS